Fatigue and drowsiness
108 adults over 65. 250 mg NMN daily for 12 weeks, randomised and placebo-controlled. Participants taking NMN in the afternoon showed significantly lower drowsiness and lower total fatigue scores than placebo. ³
Description
PureLane is 500 mg of β-nicotinamide mononucleotide per capsule. Nothing else.
NMN is the direct precursor to NAD⁺ — the coenzyme every cell in your body uses to convert food into usable energy. Your mitochondria depend on it, and so do several hundred other metabolic reactions.
NAD⁺ levels fall as you get older. A study of 1,518 adults found whole-blood NAD⁺ declining measurably through the forties. NMN sits one step away from NAD⁺: your body converts it directly, without an intermediate.
That is the whole idea. Not a stimulant, not a blend, not a proprietary formula — one compound, at a dose within the range used in published human trials, so you can look up what it does and check our work.*
How to take it
One capsule in the morning, with or without food.
Morning is the recommendation because NAD⁺ follows a daily rhythm and is naturally highest early in the day. The trial that measured drowsiness dosed participants in the afternoon rather than at night. Taking it later is not harmful — it is simply further from how the research was run.
Consistency matters more than timing. The published protocols ran daily for 8 to 12 weeks without breaks, and that is the pattern worth copying.
You can take it alongside coffee. NMN is not a stimulant and does not act on adenosine, the pathway caffeine works on.*
Ingredients & full label
No fillers. No proprietary blends. No added ingredients.
One capsule contains 500 mg of β-nicotinamide mononucleotide and the capsule shell. That is the complete list.
There is no magnesium stearate, no silicon dioxide, no rice flour, no proprietary energy matrix — none of the bulking agents that let a label look fuller than the bottle is.
Serving size: 1 capsule
Servings per container: 30
β-Nicotinamide Mononucleotide (NMN): 500 mg — daily value not established
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Testing & quality
Every batch is tested by a third-party laboratory before it ships.
Lot 6020213 was tested for NMN content, heavy metals — lead, cadmium, mercury and arsenic — and microbial contamination, covering total plate count, yeast and mould, E. coli and salmonella. All results came back within specification.
PureLane is manufactured in a cGMP-certified facility in the United States. The facility's GMP conformance was assessed by UL Solutions and is valid to November 2028.
Want the certificate of analysis for the lot in your bottle? Email us and we will send the full document.
It's not that you're lazy. It's 2pm.
Most people treat this as a discipline problem. It's usually a fuel problem.
So what's actually going on?
It's not in your head. It's in your cells.
Everything you did today — thinking, moving, staying awake through a meeting — was paid for with energy your cells made from the food you ate.
That conversion isn't automatic. It runs on machinery, and that machinery gets less efficient as you get older. Same food, same sleep, less usable energy at the end of it.
Which is why the tiredness feels different in your forties than it did in your twenties. You didn't get lazier. The supply got smaller.
The delivery system behind it
What it does. NAD⁺ carries energy from the food you eat to the parts of your cell that actually use it.
You make fewer as you age. In a study of 1,518 adults, blood NAD⁺ fell measurably through the forties. ²
NMN rebuilds the fleet. Your body converts it to NAD⁺ in a single step — no conversion chain.
Purelane NMN vs common energy boosters
PureLane NMN
|
Caffeine
|
Vitamin B
|
Magnesium
|
Creatine
| |
|---|---|---|---|---|---|
| Restores the fuel your cells run on (NAD⁺) | Yes | No | Depends on form or dose | No | No |
| No crash or dip afterward | Yes | No | Yes | Yes | Yes |
| No dependency or tolerance buildup | Yes | No | Yes | Yes | Yes |
| Won't interfere with sleep | Yes | No | Depends on form or dose | Yes | Yes |
| Works even if you're not deficient | Yes | Yes | No | No | Yes |
| No water retention or weight gain | Yes | Yes | Yes | Yes | No |
What the research says about NMN
NAD⁺ levels and physical performance
80 healthy adults aged 40–65. Placebo, 300 mg, 600 mg, or 900 mg daily for 60 days. Blood NAD⁺ rose significantly at every dose versus placebo and baseline. Six-minute walking distance improved across all NMN groups. ⁵
Aerobic capacity and endurance
48 recreational runners aged 27–50, six weeks, randomised and double-blind. Oxygen uptake and ventilatory threshold improved more in the 600 mg and 1,200 mg groups than placebo. ⁴
Liao et al., J Int Soc Sports Nutr, 2021 (opens in a new window)
Safety and tolerability
36 healthy middle-aged adults, 250 mg daily for 12 weeks. NMN was well tolerated with no adverse events reported, and elevated NAD⁺ metabolism. ⁶
Every batch is tested before it ships.
- Lot
- 6020213
- Manufactured
- 3 March 2026
- Tested for
- NMN content · Heavy metals · Microbials
- Heavy metals
- Lead · Cadmium · Mercury · Arsenic
- Microbials
- Total plate count · Yeast & mould · E. coli · Salmonella
- Result
- All within specification
- Facility
- cGMP-certified · Assessed by UL Solutions · Valid to Nov 2028
Want the certificate of analysis for the lot in your bottle? Email us and we'll send it.
What to expect
Take one capsule in the morning, with or without food. Consistency matters more than timing — the research protocols ran daily for 8 to 12 weeks.
- Weeks 1–2
Most people notice nothing yet. NAD⁺ builds gradually; this is normal.
- Weeks 2–4
In published trials, this is the window where participants began reporting changes. Some people notice sooner. Some later.
- Month 2 and beyond
The trials measuring fatigue, endurance, and NAD⁺ ran 8 to 12 weeks. That's the honest timeframe for judging whether it works for you — which is why we guarantee it for 30 days and sell it in multiples.
30 days. Risk-free.
Try PureLane for 30 days. If you don't feel a difference — or you just change your mind — email us and we'll refund you in full. Opened bottles included. You don't need to ship anything back.
No forms. No restocking fee. No fine print about how much is left in the bottle.
Every day deserves your full energy.
Not just the important ones. Not just the ones you planned for.
The ordinary Tuesday afternoon. The shift that ends when everyone else's day is starting. The hour after dinner when there's still something you wanted to do. The weekend you'd rather not spend recovering from the week.
Most people have quietly accepted that a good portion of their day is going to be spent at half capacity — and built their lives around it. Scheduled the hard things for mornings. Stopped making evening plans.
We made PureLane because that trade shouldn't be permanent. One capsule, one compound, 500 mg of pure NMN — supporting the system your cells actually use to produce energy. No blends, no filler, nothing you didn't ask for.
Your energy should last as long as your day does.
Questions
What is NMN, and how is it different from NR?
Both are precursors to NAD⁺, the coenzyme your cells use to turn food into usable energy. The difference is how many steps it takes to get there: NR (nicotinamide riboside) converts to NMN first and then to NAD⁺, while NMN converts in a single step.
Which matters more in practice is still debated, and both have human trial data behind them. We chose NMN because it is the direct precursor and because the trials closest to daily energy and fatigue used it.
When should I take it?
One capsule in the morning, with or without food.
NAD⁺ follows a daily rhythm and is naturally highest early in the day, and the trial that measured drowsiness dosed participants in the afternoon rather than at night. Taking it later is not a problem — it is just further from how the research was run.
Consistency matters more than exact timing.
How long before I notice anything?
Weeks, not days. In published trials, participants generally began reporting changes somewhere between weeks two and four, and the protocols themselves ran 8 to 12 weeks.
Some people notice sooner and some later. If you are expecting something on day one, this is the wrong product — that is what caffeine is for.
Will it keep me awake at night?
NMN is not a stimulant. It does not act on adenosine, the pathway caffeine works on, so there is no mechanism by which it would keep you up the way a coffee at 6pm does.
We suggest mornings because that is closest to how the research was run, not because taking it later causes a problem.*
Can I still drink coffee?
Yes. They are not doing the same job.
Caffeine blocks the signal that tells your brain you are tired — useful, fast, and temporary. NMN supplies a precursor your cells convert to NAD⁺, which is part of how they produce energy in the first place. One does not replace the other, and taking them together is fine.*
Is 500 mg the right dose?
Published human trials have used doses from 250 mg to 1,200 mg daily. 500 mg sits in the middle of that range.
The trials that reported lower fatigue and drowsiness used 250 mg daily; the trials that measured NAD⁺ levels and walking distance used 300 to 900 mg. We chose 500 mg as one capsule so the daily habit stays simple.
Can I take it with other supplements?
Generally yes — NMN is a single compound with no known interactions with common vitamins or minerals.
If you are taking prescription medication, are pregnant or nursing, or are managing a health condition, talk to your doctor before starting this or any supplement.
Are there side effects?
In published human trials, NMN was generally well tolerated. A 12-week trial in 36 healthy middle-aged adults taking 250 mg daily reported no adverse events.
That is not the same as a guarantee about you. If anything feels off, stop taking it and talk to your doctor.
Is NMN legal to sell as a supplement in the US?
NMN is sold widely in the United States and we ship it to all 50 states.
The regulatory position is genuinely unsettled, and we would rather you heard that from us. In 2022 the FDA took the view that NMN is excluded from the dietary supplement definition because it had previously been authorised for investigation as a new drug. Industry trade groups have contested that position, and NMN products have remained on the market since.
If that changes, we will say so here.
Is this third-party tested?
Yes. Every batch is tested by an independent laboratory before it ships — for NMN content, for heavy metals (lead, cadmium, mercury, arsenic), and for microbial contamination (total plate count, yeast and mould, E. coli, salmonella).
The lot in the current run is 6020213 and all results came back within specification. Email us and we will send you the full certificate of analysis for the lot in your bottle.
What's your return policy?
30 days, no conditions. If you do not feel a difference, or you simply change your mind, email us and we will refund you in full.
Opened bottles included. You do not need to ship anything back. No forms, no restocking fee, and no fine print about how much is left in the bottle.
Do you ship outside the US?
Not currently. We ship within the United States only.
Your energy should last as long as your day does.
One capsule each morning. 500 mg of pure NMN, nothing else.
30-day money-back guarantee · Manufactured in the USA
References
- Third-party testing — see Testing & certification
- Front Endocrinol, 2022 — whole blood NAD⁺ and aging, n=1,518. PubMed 35388296
- Kim et al., Nutrients, 2022 — PubMed 35215405
- Liao et al., J Int Soc Sports Nutr, 2021 — PMC8265078, PubMed 34238308
- Yi et al., GeroScience, 2022 — PubMed 36482258
- Scientific Reports, 2023 — NMN and NAD⁺ metabolism, 12-week RCT